American Journal of Medical and Clinical Sciences. 2017;
2(1):(8-146)
doi: 10.5455/ajrms.281647
Combined expressions of ALEX1 and HNF-1β could improve the ability of differentiation between squamous cell carcinoma and adenocarcinoma of the uterine-cervix
Hanaa A. Atwa, Mona Saeed Mohamed
Abstract
Methods: HNF-1-β and ALEX-1 protein expressions were evaluated in 32 cases of SCC and 18 cases of adenocarcinoma of the cervix. The relationships between their levels of expression and the ability of panel of both markers in differentiation between both types of carcinomas were analyzed.
Results: We observed positive staining for HNF-1β in 83.4% (15/18) of adenocarcinoma cases. The difference of HNF-1β expression between cervical SCC and adenocarcinoma was statistically significant (p < 0.001). Positive ALEX-1 expression was observed in all cases of SCC of the cervix. The difference of ALEX-1expression between cervical SCC and adenocarcinoma was statistically significant (p < 0.001). This methodology for distinguishing cervical squamous cell carcinoma and adenocarcinoma had a sensitivity of 93.8% and a specificity of 100% (p < 0.001). Conclusion: The panel of both HNF-1β and ALEX-1 expressions can help in proper subtyping of cervical carcinoma with high sensitivity and specificity.