Methods: Amyloidosis cases were identified in a large multi-center medical database using defined criteria. The presentation of CAD was determined through ICD codes for cardiac catheterization records and other precisely identifiable data, such as the history of stenting or bypass graft operations. TTR and non-TTR amyloidosis groups were compared regarding their baseline demographics, clinical, laboratory, and imaging presentations.

Results: Out of 5273 subjects in the study, 79 had TTR, and 5194 had non-TTR amyloidosis. On average, non-TTR patients are significantly older than TTR patients (70.39±13.26 vs. 63.09±19.40, p=.0013). 

Overall, CAD was present in 1221 (23.16%) subjects. The prevalence of CAD was comparable between the non-TTR and TTR amyloid groups (23.2% vs. 22.8%, p>0.05). However, hypertension was more present in the non-TTR group than in TTR (32% vs. 12%, p=.0001). Race, gender, diabetes, and hyperlipidemia did not differ between the two groups (p>0.05).

Conclusion: CAD prevalence in TTR and non-TTR is around 23%. The type of amyloidosis does not impact the prevalence of CAD.