American Journal of Medical and Clinical Sciences. 2023; 8(2):(84-126)


Mesenchymal Stem Cell-Based Therapy: Targeting Triple-Negative Breast Cancer

Heather A. Domby, Vincent S. Gallicchio.

Abstract
Across the globe, breast cancer (BC) is the most frequently identified cancer in women, with approximately 1.7 million new cases diagnosed annually. Despite current advances in cancer treatment and detection technology, breast cancer stem cells (bCSCs) within the tumor microenvironment have contributed to the rise in chemotherapy drug resistance and tumor relapse. As a result, BC remains a considerable public health threat and is of utmost importance to biomedical research. The emergence of cell-based therapies has provided promising potential in terms of clinical application, especially regarding tumor heterogeneity. Mesenchymal stem cell (MSC)-based therapy has been an attractive area of research due to the self-renewal and differentiation capabilities of MSCs. On the other hand, the use of MSCs in cancer treatment and human clinical trials is restricted by contradictory results in preclinical investigations. This review summarizes the unique attributes of MSCs and their mechanistic potential in targeting triple-negative breast cancer (TNBC). It addresses preclinical risk factors associated with MSC-based therapy and future direction to improve therapeutic utility.
Most Viewed Article
  • Evaluation of Effectiveness of Modified Pediatric Constraint-Induced Movement Therapy Performed on Children with Cerebral Palsy by a Home-Treatment Program
    Hiroshi Tanabe, Hirofumi Tanabe, Shosaku Okuda, Toshimasa Mikawa, Yoshimi Sakurai, Yuichi Takata.
    » Abstract » doi: 10.33425/2832-4226/25001

  • Risk Factors Associated with the Onset of Diabetes Mellitus in Patients with A History of Gestational Diabetes at The University Hospital of Kinshasa
    Tandu Umba A, Mbungu Mwimba R, Kahindo Muyayalo P, Mbangama Muela A, Lumaya Ambis J, Mwimba Mbungu N, Kelele Goy Sambwa, Lukunda Diansambu P, Kinkenda Nsiangangu B.
    » Abstract » doi: 10.33425/2832-4226/24025

  • Crisis of Soul II
    Julian Ungar-Sargon
    » Abstract » doi: 10.33425/2832-4226/24024

  • The Importance of Family Involvement in the Treatment of Pediatric Obsessive-Compulsive Disorder
    Eda Gorbis, Jenny C Yip, Aanya Jajoo.
    » Abstract » doi: 10.33425/2832-4226/24023

  • Double Diabetes: Insulin Resistance and Metabolic Syndrome in Sudanese Patients with Type 1 Diabetes Mellitus
    Alaa Ali Elsharief Hammad, Abdelaziz SI, Salih H. S. Hamid.
    » Abstract » doi: 10.33425/2832-4226/24022

Most Downloaded
  • Evaluation of Effectiveness of Modified Pediatric Constraint-Induced Movement Therapy Performed on Children with Cerebral Palsy by a Home-Treatment Program
    Hiroshi Tanabe, Hirofumi Tanabe, Shosaku Okuda, Toshimasa Mikawa, Yoshimi Sakurai, Yuichi Takata.
    » Abstract » doi: 10.33425/2832-4226/25001

  • Risk Factors Associated with the Onset of Diabetes Mellitus in Patients with A History of Gestational Diabetes at The University Hospital of Kinshasa
    Tandu Umba A, Mbungu Mwimba R, Kahindo Muyayalo P, Mbangama Muela A, Lumaya Ambis J, Mwimba Mbungu N, Kelele Goy Sambwa, Lukunda Diansambu P, Kinkenda Nsiangangu B.
    » Abstract » doi: 10.33425/2832-4226/24025

  • Crisis of Soul II
    Julian Ungar-Sargon
    » Abstract » doi: 10.33425/2832-4226/24024

  • The Importance of Family Involvement in the Treatment of Pediatric Obsessive-Compulsive Disorder
    Eda Gorbis, Jenny C Yip, Aanya Jajoo.
    » Abstract » doi: 10.33425/2832-4226/24023

  • Double Diabetes: Insulin Resistance and Metabolic Syndrome in Sudanese Patients with Type 1 Diabetes Mellitus
    Alaa Ali Elsharief Hammad, Abdelaziz SI, Salih H. S. Hamid.
    » Abstract » doi: 10.33425/2832-4226/24022