American Journal of Medical and Clinical Sciences. 2018; 3(2):(27-126)


Interaction of nanoparticles with central nervous system and its consequences

Sairanthry Suku Athira, Nadukkandy Prajitha, Parayanthala Valappil Mohanan

Abstract
Nanotechnology has gained a non-replaceable role in a host of applications in biomedical, agricultural, consumer, military, and in industrial sectors. However, when observed through the perspective of the central nervous system (CNS) particularly, studies evidently provide data on both beneficial and detrimental effects of nanoparticles (NPs). While there exist a milieu of beneficial applications like axonal regeneration, CNS imaging, neurological surgeries etc., NPs open the doorway for an array of toxic reactions in CNS centers because of their effortless passage through brain barriers. Even though literature endow with generalized toxic mechanisms mediated by NPs in varying tissues, specific toxic reactions in CNS are still lacking. Present review mainly focuses on different routes through which NPs get access into the brain and certain modes of toxic mechanisms exhibited by NPs in CNS. A number of applications of NPs in the diagnosis and treatment of CNS disorders also will be reviewed in concise.
Most Viewed Article
  • Evaluation of Effectiveness of Modified Pediatric Constraint-Induced Movement Therapy Performed on Children with Cerebral Palsy by a Home-Treatment Program
    Hiroshi Tanabe, Hirofumi Tanabe, Shosaku Okuda, Toshimasa Mikawa, Yoshimi Sakurai, Yuichi Takata.
    » Abstract » doi: 10.33425/2832-4226/25001

  • Risk Factors Associated with the Onset of Diabetes Mellitus in Patients with A History of Gestational Diabetes at The University Hospital of Kinshasa
    Tandu Umba A, Mbungu Mwimba R, Kahindo Muyayalo P, Mbangama Muela A, Lumaya Ambis J, Mwimba Mbungu N, Kelele Goy Sambwa, Lukunda Diansambu P, Kinkenda Nsiangangu B.
    » Abstract » doi: 10.33425/2832-4226/24025

  • Crisis of Soul II
    Julian Ungar-Sargon
    » Abstract » doi: 10.33425/2832-4226/24024

  • The Importance of Family Involvement in the Treatment of Pediatric Obsessive-Compulsive Disorder
    Eda Gorbis, Jenny C Yip, Aanya Jajoo.
    » Abstract » doi: 10.33425/2832-4226/24023

  • Double Diabetes: Insulin Resistance and Metabolic Syndrome in Sudanese Patients with Type 1 Diabetes Mellitus
    Alaa Ali Elsharief Hammad, Abdelaziz SI, Salih H. S. Hamid.
    » Abstract » doi: 10.33425/2832-4226/24022

Most Downloaded
  • Evaluation of Effectiveness of Modified Pediatric Constraint-Induced Movement Therapy Performed on Children with Cerebral Palsy by a Home-Treatment Program
    Hiroshi Tanabe, Hirofumi Tanabe, Shosaku Okuda, Toshimasa Mikawa, Yoshimi Sakurai, Yuichi Takata.
    » Abstract » doi: 10.33425/2832-4226/25001

  • Risk Factors Associated with the Onset of Diabetes Mellitus in Patients with A History of Gestational Diabetes at The University Hospital of Kinshasa
    Tandu Umba A, Mbungu Mwimba R, Kahindo Muyayalo P, Mbangama Muela A, Lumaya Ambis J, Mwimba Mbungu N, Kelele Goy Sambwa, Lukunda Diansambu P, Kinkenda Nsiangangu B.
    » Abstract » doi: 10.33425/2832-4226/24025

  • Crisis of Soul II
    Julian Ungar-Sargon
    » Abstract » doi: 10.33425/2832-4226/24024

  • The Importance of Family Involvement in the Treatment of Pediatric Obsessive-Compulsive Disorder
    Eda Gorbis, Jenny C Yip, Aanya Jajoo.
    » Abstract » doi: 10.33425/2832-4226/24023

  • Double Diabetes: Insulin Resistance and Metabolic Syndrome in Sudanese Patients with Type 1 Diabetes Mellitus
    Alaa Ali Elsharief Hammad, Abdelaziz SI, Salih H. S. Hamid.
    » Abstract » doi: 10.33425/2832-4226/24022