American Journal of Medical and Clinical Sciences. 2023;
8(3):(89-126)
Haematological Profiles of Plasmodium-Induced Changes in Serum Amyloid-A levels among the Internally Displaced Persons in Maiduguri
EZE Chinwe N, EBENEZER Amawulu.
Abstract
The menace of malaria has constituted a health challenge in Nigeria. Internally Displaced
Persons’ Camps are available temporary accommodation provided for victims of war in war
torn zones around the world. A study was undertaken to investigate relationship between
Serum Amyloid A (SAA), haematological profiles and malaria infection among internally
displaced person in three (3) different camps (GGC: Government Girls’ College Camp, GSS:
Girls’ Secondary School Camp, CAN-: Christian Association of Nigeria) within Maiduguri,
Borno state capital between March and September, 2017. A total of 400 sample subjects
were recruited for the study, malaria parasite test was done using the Giemsa thick and
thin peripheral blood film, SAA was analysed using the Enzyme linked immune-sobent
assay (ELISA) kit while Haematological parameters were analyse using the automatic full
blood count analyser. The result of the study shows a positive correlation between malaria
infection and these parameters. A mean SAA of 32.76mg/l, PCV of 28.2%, haemoglobin
of 8.88g/dl, platelets of 116.54×103
/µl, leucocyte of 6.02×103
/mm3 and neutrophils
of 3.34×103
/mm3 was recorded in the positive subjects compared to the 14.11mg/l,
41%, 14.81g/dl, 261.46×103/µl, 8.23×103
/mm3
, 4.11×103
/mm3 reported in the negative
patients group, this results shows that there are abnormal haematological alterations in
malaria subjects compared to the negative control group, hence SAA and haematological
parameters can be used as markers of plasmodium infection.
