American Journal of Medical and Clinical Sciences. 2017;
1(1):(4-148)
doi: 10.5455/ajrms.281388
Effect of edible camphor administrations on levels of steroid and thyroid hormones in male wistar rats
Oluwatobi T Somade, Regina N Ugbaja, Abdullahi A Adebayo
Abstract
Methods: Thirty rats were used for the study, and were divided into six groups of five rats each. Group I animals served as normal control, group II animals served as vehicle control and were orally administered 6 mL/kg corn oil, while groups III, IV, V, and VI animals were orally administered 1, 2, 4, and 6 g/kg EC for seven days.
Results: Following EC administrations, there was significant (p < 0.05) decrease in serum total cholesterol (TCHOL) by 4 and 6 g/kg body weight EC. Furthermore, luteinizing hormone (LH), testosterone (TST), and thyroid stimulating hormone (TSH) levels were significantly reduced by the various doses. Conversely, 2 and 4 g/kg EC significantly increased the serum level of free triiodothyronine (fT3), but was significantly reduced by 6 g/kg EC, and lastly, EC administrations did not have any significant effect on serum prostate specific antigen (PSA). Conclusion: We therefore concluded that the use of EC should be with caution, and may contribute to thyroid and hormonal disruption in rats.