American Journal of Medical and Clinical Sciences. 2026;
11(1):(148-148)
Addition of Lemborexant to Bromazepam Therapy for Chronic Insomnia in a Patient Receiving Tirzepatide for Metabolic Dysfunction-Associated Steatohepatitis: A Longitudinal Observational Study of Sleep Duration and Dream Occurence
Hsin-Fu Chen, Sheng-Yang Chen, Ting-Wei Chen, Chia-Yu Chou, Hsin-Yu Chen, Tsung-Yi Chen.
Abstract
In a patient with chronic insomnia already under
bromazepam 3 mg treatment, the addition of lemborexant 5 mg prolonged the sleep
duration from 6.3 hours to 7.2 hours. The combination therapy of lemborexant
and bromazepam might prolong sleep duration than using romazepam alone in a
metabolic dysfunction-associated steatohepatitis (MASH) patient under weekly subcutaneous
tirzepatide (Mounjaro) treatment. Moreover, this literature highlights a potential
association between the addition of lemborexant and the occurrence of dreams in
a patient receiving chronic bromazepam therapy.