Methods: Twenty-five male albino rats were used in this research work. The rats were divided into five groups of five animals each. Group I: control; received normal rat feed + distilled water, Group II: received normal rat feed + 125 μg/kg of CTR, Group III: received normal rat feed + 10% fructose drinking rats (FDR), Group IV: received normal rat feed + 10% fructose solution (FDR) + 0.3 mg/kg of glibenclamide (GLIB), and Group V: received normal rat feed + 10% fructose solution (FDR) + 125 μg/kg of CTR. For the induction of hyperglycemia and lipidemia, rats were given 10% fructose solution as drinking water for 8 weeks. The levels of fasting sugar and glycated hemoglobin (HbA1c) were measured. Changes in body weights and lipid profile of rats were determined. 

Results: CTR group exhibited no significant (P < 0.05) change in plasma glucose levels, HbA1c, and body weights when compared to the control (5.09 ± 0.45 mmol/l vs. 5.20 ± 0.15 mmol/l, 4.57% ± 0.24% vs. 4.29% ± 0.31%, and 193.0 ± 12.25 g vs. 189.2 ± 6.37 g, respectively). In FDR group, fasting sugar levels, HbA1c, and weights were found to be significantly (P < 0.05) increased when compared to group I (6.49 ± 0.16 mmol/l vs. 5.20 ± 0.15 mmol/l, 5.23% ± 0.17% vs. 4.29% ± 0.31%, and 219.1 ± 17.36 g vs. 189.2 ± 6.37 g, respectively). Glibenclamide administration in GLIB + FDR group effectively abolished the fructose-induced hyperglycemia and HbA1c in rats when compared to FDR group (5.53 ± 1.92 mmol/l vs. 6.49 ± 0.28 mmol/l and 4.10% ± 0.54% vs. 5.23% ± 0.17%, respectively). In FDR + CTR group, CTR supplementation successfully blocked and prevented the fructose-induced increase in fasting sugar, HbA1c levels, and weight in rats when compared with FDR group (5.12 ± 0.39 mmol/l vs. 6.49 ± 0.28 mmol/l, 4.43% ± 0.24% vs. 5.23% ± 0.17%, and 192.2 ± 11.23 g vs. 219.1 ± 17.36 g, respectively). CTR group exhibited no significant (P > 0.05) changes in lipid profile parameters when compared to control (3.88 ± 0.19 mmol/l vs. 3.89 ± 0.38 mmol/l, 1.20 ± 0.16 mmol/l vs. 1.12 ± 0.11 mmol/l, 2.16 ± 0.17 mmol/l vs. 2.20 ± 0.22 mmol/l, and 1.32 ± 0.22 mmol/l vs. 1.30 ± 0.16 mmol/l) for total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), and high density lipoprotein (HDL), respectively. FDR exhibited a significant (P < 0.01) increase in serum TC (4.90 ± 0.23 mmol/l) when compared to control group (3.88 ± 0.19 mmol/l). Similarly, fructose feeding resulted in a significant elevation (P < 0.01) in TGs levels (1.90 ± 0.27 mmol/l vs. 1.20 ± 0.16 mmol/l) in comparison to the corresponding control rats. In addition, FDR group rats had elevated levels of LDL-cholesterol (LDL-C) which was significant (P < 0.05) when compared with the corresponding control group (2.80 ± 0.26 mmol/l vs. 2.16 ± 0.17 mmol/l). Although, HDL-C was increased in FDR group, the increase was not significant (P > 0.05) and the result was comparable to that of the control (1.22 ± 0.07 mmol/l