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Addition of Lemborexant to Bromazepam Therapy for Chronic Insomnia in a Patient Receiving Tirzepatide for Metabolic Dysfunction-Associated Steatohepatitis: A Longitudinal Observational Study of Sleep Duration and Dream Occurence

Hsin-Fu Chen, Sheng-Yang Chen, Ting-Wei Chen, Chia-Yu Chou, Hsin-Yu Chen, Tsung-Yi Chen.

Abstract

In a patient with chronic insomnia already under bromazepam 3 mg treatment, the addition of lemborexant 5 mg prolonged the sleep duration from 6.3 hours to 7.2 hours. The combination therapy of lemborexant and bromazepam might prolong sleep duration than using romazepam alone in a metabolic dysfunction-associated steatohepatitis (MASH) patient under weekly subcutaneous tirzepatide (Mounjaro) treatment. Moreover, this literature highlights a potential association between the addition of lemborexant and the occurrence of dreams in a patient receiving chronic bromazepam therapy.